Multifaceted Approaches to Delineate the Structural and Functional Determinants of Follicle Stimulating Hormone Receptor
نویسندگان
چکیده
The interaction of follicle stimulating hormone (FSH) with its cognate G-protein coupled receptor, the follicle stimulating hormone receptor (FSHR) is crucial for folliculogenesis in females and spermatogenesis in males. This necessitates the delineation of the hormone-receptor interaction in greater detail at the molecular level. Several strategies have been employed over last two decades to delineate the hormone-receptor interaction at structural, molecular and cellular level. Here, we have attempted to summarize the work carried out using synthetic peptides and anti-peptide antibodies corresponding to the predicted potential functional epitopes of FSHR, site-directed mutagenesis, naturally occurring mutations and single nucleotide polymorphisms. The collation of information from the methods discussed will presumably prove to be useful in designing modulators of FSH action and enable better understanding of the involvement of various residues or domains of the receptor in its function. The information will also possibly help in developing predictive markers of ovarian response in women undergoing assisted reproductive techniques.
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